WebThe IRFs are involved in various host-defense and antioncogenic processes. For example, the Irf1−/− mouse embryonic fibroblasts (MEFs) are readily transformed by the Ha-ras … WebIRF1 is a broadly acting antiviral effector and exhibits tumor-suppressor functions in multiple cellular contexts ( 24, 25 ). With respect to PDA, prior studies have shown that IRF1 can promote a differentiated epithelial cell state and inhibit cell proliferation ( 26, 27 ).
Batf2/Irf1 induces inflammatory responses in classically activated ...
WebApr 11, 2024 · IFNγ binds a specific cell-surface receptor complex, a heterodimer of IFNGR1 and IFNGR2, expressed in most cell types, which employ JAK1 and JAK2 to phosphorylate STAT1 (pSTAT1). pSTAT1 homodimers translocate to the nucleus and stimulate the expression of a set of genes, including transcription factors such as IFN regulatory factor … WebNov 23, 2012 · The NBD contains a Walker A motif (also known as a P-loop; a nucleoside triphosphate (NTP) binding site) and a Walker B motif (an NTP hydrolysis site), which are … cindy wooten state of alabama
IRF1 Gene - GeneCards IRF1 Protein IRF1 Antibody
WebMar 21, 2024 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Lung Cancer and Gastric Cancer.Among its related pathways are Bacterial infections in CF airways and Overview of interferons-mediated signaling pathway.Gene Ontology (GO) annotations related to this gene include DNA-binding … WebDec 8, 2024 · SPOP-binding consensus motif in IRF1 is required for SPOP-mediated IRF1 destruction Previous studies have reported that one or more SBC motifs are present in SPOP substrates [ 9 ]. We... WebNov 1, 2011 · To validate the IRF1 binding motif, we performed another run of IRF1 ChIP-seq which included an independent pair of input DNA and IRF1 ChIP-seq samples. Although both samples had substantially lower numbers of aligned reads (20.4 and 20.7 millions … Introduction. The differentiation of CD4 + T cells into type 1 (Th1) or type 2 (Th2) T … Viral infections commonly induce expression of type I interferon (IFN) … Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 … Little is known about the molecular mechanisms and transcriptional … Total cellular protein was prepared from cell populations treated for 24 h with … diabetic medicine and sluggishness