Atf2 myeloid

Author: edag

August undefined, 2024

WebAcute myeloid leukemia. ATF2. Activating transcription factor 2. AT-MSC. Adipose tissue-derived mesenchymal stem/stromal cell. BAD. Bcl-2-associated death promoter. … WebJun 27, 2016 · We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase …

Co-regulation of the transcription controlling ATF2 ... - Nature

WebFull gene name according to HGNC. Activating transcription factor 2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. … WebATF2 with a tissue-specific coactivator activating signal cointegator-2 (ASC-2) potentiates the differentiation pro-cedure. ... lineages, erythroid, myeloid, or lymphoid cells (1). The vitamin A metabolite, all-trans retinoic acid, induces the granulocytic differentiation of the promyelocytic cell line U937, similar to HL60. cheap sam hunt tickets

The ROS/JNK/ATF2 pathway mediates selenite-induced leukemia …

WebDec 19, 2013 · ATF2 regulates cell cycle-related protein expression. JNK has an important role in modulating cell cycle progression. ATF2, a transcription factor, has also been … WebApr 15, 2010 · Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. This Perspective summarizes the emerging role of the transcription factor ATF2 ... WebApr 4, 2024 · basic leucine zipper transcriptional factor ATF-like 2, B-ATF-2, basic leucine zipper transcription factor, ATF-like 2, suppressor of AP-1 regulated by IFN. ... Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs ... cheap same day theatre tickets

Activating Transcription Factor 2 - an overview

WebIn this study, we show two novel points that ATF2 is re-quired for the induction of granulocytic differentiation and associates with granulocyte-specific transcription factor … WebThe gene atf2 is located at human chromosome 2q32. The protein ATF-2 has 505 amino acids. Studies in mice indicate a role for ATF-2 in the development of nervous system and the skeleton. ATF-2 is normally activated in response to signals that converge on stress-activated protein kinases p38 and JNK. cyber security computer definitionWebMay 9, 2012 · Prostaglandin I(2) (PGI(2)) analog is regarded as a potential candidate for treating asthma. Human myeloid dendritic cells (mDCs) play a critical role in the pathogenesis of asthma. ... (2+) pathway. Iloprost suppressed TNF-α expression via the MAPK-p38-ATF2 pathway and epigenetic regulation by downregulation of histone H3K4 … cheap same day flowers sydney

"WebJun 3, 2024 · ATF2 can contribute to regulating the expression of matrix metalloproteases (MMPs), which are zinc-dependent neutral endopeptidases that play an essential role in the process of tissue remodelling by degrading extracellular matrix (ECM) components. 41, 42 A recent study confirmed that ERK1 mediates IL-1β activation of the ERK1/ATF2 signalling ... " - Atf2 myeloid

Atf2 myeloid

JNK1/c-Jun and p38α MAPK/ATF-2 pathways are responsible for ...

WebJan 27, 2024 · Summary. Basic leucine zipper ATF-like transcription factor 2 (BATF2), an interferon-activated immune response regulator, is a key factor responsible for myeloid … WebWe further demonstrated that LPS stimulated ATF2 and p300 phosphorylation and complex formation via a c-Src/NADPH oxidase/ROS/p38 MAPK pathway. Up-regulation of VCAM-1 led to enhancing monocyte adhesion to HRMCs challenged with LPS, which was inhibited by siRNAs of c-Src, p47phox, p38 MAPK, ATF2, and p300 or pretreatment with an anti …

Did you know?

WebDiscover Atf2's significant phenotypes, expression, images, histopathology and more. Data for gene Atf2 is all freely available for download. Cite IMPC; Help; ... Aplastic anemia, Myeloid leukemia, Myelodys... OMIM:614172: Bleeding Disorder, Platelet-Type, 16: Impaired platelet aggregation, Macrothrombocytopenia, Giant platelets, Platelet ...

WebCharacterization of ATF2 dysfunction in the context of pathological conditions, particularly in cancer biology and response to therapy, will be important in understanding how pathways controlled by ATF2 or other transcription factors might be therapeutically exploited. In this review, we provide an overview of the currently known upstream ... WebJun 15, 2012 · The ATF2 gene is located on chromosome 2q32 and encodes a 505-amino-acid protein, which is ubiquitously expressed, with more abundant expression in the brain (Kara et al., 1990; Takeda et al., 1991).Although the existence of numerous truncated ATF2 isoforms is predicted on the basis of splice variation (), only full-length ATF2 has been …

WebNov 16, 2024 · Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer endocrine resistance is still unclear. We have previously shown that silencing of ATF2 leads to a loss in the growth-inhibitory … WebSep 21, 2024 · Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The word "acute" in acute myelogenous leukemia denotes the disease's rapid progression. It's called myelogenous (my-uh-LOHJ-uh-nus) leukemia because it affects a group of white blood …

WebDec 22, 2024 · ATF4 deletion caused expansion of phenotypical HSCs with functional attrition, characterized by defective repopulating and self-renewal capacities and …

http://www.cancer-genetics.org/ATF2.htm cheap samos flightsWebDec 19, 2013 · ATF2 regulated cell cycle-related protein expression and inhibited apoptosis in selenite-treated NB4 cells. (a) ATF2 bound to the promoters of cyclin D3, cyclin A and CDK4. A ChIP assay was ... cheap samplersWebOct 15, 2009 · Request PDF JNK1/c-Jun and p38α MAPK/ATF-2 pathways are responsible for upregulation of Fas/FasL in human chronic myeloid leukemia K562 cells upon exposure to Taiwan cobra phospholipase A 2 ... cyber security computer stickerWebJun 23, 2024 · Correlation analysis results showed that T cell CD8+ was positively correlated with myeloid dendritic cell but was negatively correlated with cancer … cyber security.com 個人情報漏洩事件・被害事例一覧WebATF2 is part of cluster 44 Non-specific - Transcription with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore … cheap sample carton of cigarettesWebMay 1, 2024 · 1. Activating transcription factor 2 (ATF2) Activating transcription factor 2 (ATF2)—also known as cyclic AMP (cAMP) response element (CRE) binding protein 2 (CREB2) and CRE-BP1—is a member of the activating protein-1 (AP1) transcription factor family that regulates gene expression through homo-dimerization or hetero-dimerization … cheap sampler machineWebJan 27, 2024 · In contrast, myeloid colony formation was significantly enhanced on administration of CCL5 (Figures 7D and S7I). These findings reveal that CCL5 treatment is sufficient to rescue the myeloid differentiation in Batf2 KO mice. Collectively, the results suggest that BATF2 promotes myeloid differentiation through activation of CCL5. cyber security computer